Side Effects Of Anticancer Drugs Slideshare

Of pharmaceutical chemistry chilukur balaji college of pharmacy e mail.

Side effects of anticancer drugs slideshare.

Diarrhoea neutropenia thrombocytopenia cholinergic side effects 75. Chemical carcinogenesis generally takes several 10 40 years to develop. Usually used in combination chemotherapy orally effective bone marrow depression 1. Drug induced disease also called iatrogenic physician induced diseases.

Name clinical uses common side effects of drug altretamine treatment ofadvanced ovarian cancer bone marrowdepression nausea and vomiting asparaginase commonly used in combination with other drugs. E g. Mutagenecity and carcinogenicity capacity of a drug to cause genetic defects and cancer respectively. There are many different types of targeted drugs and their side effects depend largely on the type of drug that s given and what it targets.

Anticancer antibiotics cell cycle non specific drugs derived from streptomyces species moa. Intercalation in the dna between adjoining nucleotide pairs blocks dna rna. Anticancer drugs the anticancer drug either kill cancer cells or modify their growth. Chemotherapy of anticancer drugs 1 s seetaram swmy m pharm asst.

Chemotherapy radiotherapy immunotherapy surgery 10. Used in metastatic cancer of colon rectum toxicity. Targeted therapy drugs have different side effects than standard or traditional chemotherapy. Monoclonal antibodies are biological drugs used to treat cancers certain types of arthritis lupus ms and ibd.

Anti cancer drugs 1. Some targeted drugs have very few side effects and others can cause more or more serious problems. Side effects 2 pyrimidine analogs. Side effects are itching rash chills cough and constipation and may include hepatitis cancer and congestive heart failure.

Discovery of anticancer agents started after 1940 s when nitrogen mustard was used most of the agents were discovered in 1950 1970. Anticancer drugs radio isotypes estrogens tobacco. Also used for induction of remission acute lymphoblastic leukemia non hodgkin s lymphomas. Chemotherapy the aim of chemotherapy is to do the maximum damage to cancer cells while causing the minimum damage to healthy tissue it is the use of cytotoxic drugs to destroy cancer cells chemotherapy affects the entire body.

Azacitidine sold under the brand name vidaza among others is a chemical analog of cytidine a nucleoside in dna and rna azacitidine and its deoxy derivative decitabine also known as 5 aza 2 deoxycytidine are used in the treatment of myelodysplastic syndrome both drugs were first synthesized in czechoslovakia as potential chemotherapeutic agents for cancer. Cytosine arabinoside inhibits dna synthesis most effective agent for induction of remission in acute myelocytic leukemia.